Anti-Hexosaminidase Antibody Development
Hexosaminidases are lysosomal glycosidase enzymes responsible for the hydrolysis of terminal N-acetyl-D-hexosamine residues from N-acetyl-β-D-hexosaminides. In humans and other mammals, the system is primarily composed of two major isoenzymes: Hexosaminidase A (Hex A), a heterodimer of α and β subunits, and Hexosaminidase B (Hex B), a homodimer of β subunits. These enzymes play a critical biological role in the degradation of gangliosides and other glycoconjugates within the lysosome.
