RSVSR Guide Help You Find the Best Areas to Farm Runes in Diablo 2
One of the best places to farm high runes is without a doubt, the secret cow level. To access the secret level, however, you would need to have done some preparation. To create a portal to the Cow Level, you would first need to have killed the final boss of that difficulty and then combine a Wirt’s Leg and a Tome of Town Portal in the Horadric Cube while standing in the rogue encampment.
This is a very good farming location due to ghosts. In Diablo II, ghosts have a smaller, limited drop pool compared to other enemies. Which means that your chances of them dropping a High Rune are higher. It’s important to note that you need to kill them while they are standing on the path (space area) otherwise they will not drop any items at all. There is also a super chest at the end of each platform and you can run into the Summoner, which has a fair chance of dropping a High Rune.